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Continue to the Natural Dos Calm+ CBDA softgel offer.
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Doctor-formulated · Raw CBDA
Dr. Colin Reily, Ph.D. and Dr. Luigi Bertoli, M.D. explain why raw, unheated CBDA absorbs over 5X better than standard CBD, and why you can feel it in 15 to 30 minutes.
Almost every hemp supplement on store shelves uses standard CBD produced with industrial heat. That heat destroys hemp's most potent raw compound and leaves a form your digestive tract barely absorbs. About 94% passes straight through.
Natural Dos co-founders Dr. Colin Reily (Ph.D., cannabinoid biochemistry) and Dr. Luigi Bertoli (M.D., internal medicine) developed a low-temperature extraction that preserves unheated Natural Spectrum CBDA (cannabidiolic acid).
Published research shows CBDA absorbs over 500% (5X) more efficiently than regular CBD and acts directly on your brain's 5-HT1A serotonin pathway, for mental and physical calm you can feel within 15 to 30 minutes, without THC, sugar, or morning grogginess.
The BOGO package
No more 3am wake-ups staring at the ceilingMarcus T. · Verified buyer
Finally something that works on my nervous systemLauren M. · Verified buyer
Was skeptical about the science, now convincedC. F. · Verified buyer
My daily evening ritual. No taste, no sugarLinda K. · Verified buyer
Incredible value on the BOGO packageTom B. · Verified buyer
For years, patients and colleagues asked us the same question.
“Why does CBD feel like an expensive placebo?”
Dr. Luigi Bertoli saw it in his practice: patients taking store-bought CBD capsules for stress and broken sleep, month after month, and reporting no real relief.
Dr. Colin Reily went looking for the reason in the biochemistry. Standard extraction heats hemp to over 200°F, a step called decarboxylation. That heat changes the molecule. It destroys the plant's native acid form, CBDA, and leaves behind CBD, which the human digestive tract struggles to absorb.
So we stopped buying commercial extracts. We spent two years refining a low-temperature extraction that captures CBDA in its raw state, then paired it with organic coconut MCT oil in a softgel with a precise, physician-set dose.
Dr. Colin Reily, Ph.D. · Co-founderIf nothing has worked, that is not on you. Most of what gets sold for stress and sleep fails for a predictable reason.
Trying harder with the wrong delivery system never works. The problem was never you. It was absorption.
Standard hemp products use high heat during extraction. Heat destroys raw CBDA and converts it to CBD.
Peer-reviewed pharmacokinetic research puts the oral bioavailability of standard CBD at roughly 6%. CBD is fat-soluble, and your liver breaks most of it down before it reaches circulation.
You are not resistant to hemp. Your body simply cannot absorb heat-treated CBD.
Cannabidiolic acid (CBDA) is the compound hemp actually makes. Skip the heat and it stays intact, and that changes everything downstream.
Cannabidiolic acid is the parent compound hemp produces naturally. It is raw, unheated, and molecularly intact. CBD is what is left after heat breaks CBDA down.
CBDA carries a carboxyl group that CBD loses to heat. That small difference lets it cross the intestinal lining far more easily, producing blood levels over 5X higher in published pharmacokinetic studies.
Standard CBD mostly interacts with general endocannabinoid receptors. Raw CBDA goes a step further and acts directly on 5-HT1A serotonin receptors, the pathway your brain relies on for emotional composure.
Every softgel pairs 50mg of raw CBDA with 50mg of CBD in organic coconut MCT oil. The CBD further supports CBDA uptake, and the MCT oil gives steady support for 6 to 8 hours.
Gut absorption
Calm you can feel in 15 to 30 minutes
Cannabinoids per piece
4X to 6X more, and 200mg in the two-softgel serving
Serotonin activity
Works on the pathway behind stress and composure
Carrier
Steady support for 6 to 8 hours
Sugar
Clean delivery right before bed
THC
Third-party tested on every batch
Calm+ is not a sedative and not a one-night trick. It works the first night, and it works better with consistency.
You take your serving with water. Within 15 to 30 minutes, physical tension softens. Shoulders drop, your jaw unclenches, and the mental chatter stops looping. Sleep arrives naturally.
Fewer jolts awake in the dark. More nights you sleep straight through to your alarm and wake clear-headed, with no morning fog.
One softgel before a high-pressure afternoon keeps the 2pm stress spiral from building. Composed, focused, and still sharp.
With consistent daily use, everyday stressors hit less hard. Deep sleep and daytime calm start to feel like your normal.
Typical experience reported by customers. Individual results vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
For two years I woke up like clockwork at 3:15am with racing thoughts. Taking Calm+ softgels before bed and I sleep straight through until 7am. I didn't believe hemp could work this well until I experienced CBDA.
I have tried virtually every CBD oil and anxiety supplement on the market and never felt a thing. With Calm+ softgels I felt a noticeable physical easing within 25 minutes of taking my serving. My brain stops spinning at night and I fall asleep easily. This is my fourth order.
Regular CBD gummies never did anything for me so I almost passed on this. The research on CBDA absorption convinced me to try the BOGO. The difference in how I handle workday pressure is night and day, and my sleep has been the deepest it has been in a decade.
I love that these are clean softgels without sugar or weird gummy flavorings. I take two after dinner with water and by 10pm my mind is quiet. Unlike melatonin, which made me groggy until noon, I wake up sharp and refreshed.
Two bottles gives you 120 softgels with 6,000mg of cannabinoids in each one, a full two-month supply for the price of a single bottle. Knowing real doctors and biochemists formulated it makes all the difference.
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Amber glass shields raw CBDA from light, so the last softgel is as potent as the first.
Take 1 to 2 tasteless softgels 30 to 60 minutes before bed, or before a stressful afternoon. First time? Start with one.
Within 15 to 30 minutes, tension lets go. No bitter taste, no sugar, and nothing to chew after you brush your teeth.
Calm
Sleep
Zero Sugar
21+ Adults
120 softgels · 100mg CBDA + 100mg CBD per serving
Natural Spectrum Hemp Extract (raw cannabidiolic acid, CBDA), CBD isolate, organic MCT oil from coconut, bovine gelatin, glycerin, purified water.
Gluten free, non-GMO, zero sugar, zero carbs, keto friendly. No artificial flavors, colors or preservatives.
Every batch is independently tested and certified for potency, purity and safety. We test for heavy metals, pesticides, microbials and residual solvents so what is printed on the label is what is in your bottle. See our Calm+ softgel CoA HERE.
Take 2 softgels with a glass of water 30 to 60 minutes before bed, or 30 to 60 minutes before a stressful situation or a busy afternoon.
First-time users can start with 1 softgel (50mg CBDA + 50mg CBD) to gauge their response. The full serving is 2 softgels.
At 2 softgels daily, your 2-bottle BOGO order is a full 2-month supply. At 1 softgel daily it lasts up to 4 months. Most people feel a calming softening within 15 to 30 minutes, and the balancing effect compounds over 2 to 4 weeks of daily use.
Calm+ softgels are for people who want a clean delivery with nothing extra.
Product not suitable for pregnant or underage individuals.
No. 11 · Honest answers
CBDA is the raw compound living hemp plants actually produce. CBD is what CBDA becomes when it is heated, a process called decarboxylation. Almost every manufacturer applies that heat during processing.
Your body absorbs CBDA over 500% more efficiently than CBD. That is the whole reason most CBD products disappoint people. Not because hemp does not work, but because they are getting the less bioavailable compound.
Calm+ leads with raw CBDA and pairs it with CBD, because CBD further enhances how much of the CBDA your body takes in.
No. Calm+ softgels contain 0.0% THC, confirmed by third-party lab testing on every batch. No intoxication, no altered state, and no concern on a standard workplace screening.
Because standard oral CBD has a bioavailability of only around 6%. If you swallowed 25mg or 50mg of CBD, your body absorbed a small fraction of it.
Calm+ solves the absorption problem by leading with raw CBDA, which research puts at 5 to 10 times better absorbed. We also pair 50mg CBDA with 50mg CBD in organic MCT oil, which research indicates further boosts cellular uptake.
Calm+ softgels are for people who want a clean delivery with nothing extra.
Most people report physical softening, settled breathing and quieter thoughts within 15 to 30 minutes.
The steady release from organic MCT oil gives 6 to 8 hours of support, which is what makes it suited to sleeping through the night. With consistent daily use over 14 to 30 days, CBDA helps regulate your baseline so everyday stressors hit less hard.
Your purchase is risk-free. When your order arrives, open and use the first bottle for up to 100 days. If you are not satisfied with how you feel during the day or how you sleep at night, email [email protected].
Keep the bottle you opened with our compliments, send back the unopened second bottle on our prepaid return label, and we refund your full purchase price.
Buy one bottle of doctor-formulated Calm+ CBDA softgels and get the second bottle free. Quieter evenings and uninterrupted sleep can start tonight.
A selection of peer-reviewed research on cannabidiolic acid (CBDA), its pharmacology, its bioavailability, and its mechanisms of action in anxiety, sleep and endocannabinoid pathways.
1. Takeda S, et al. Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metab Dispos. 2008;36(9):1917-21. PMID: 18556441
2. Bolognini D, et al. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol. 2013;168(6):1456-70. PMID: 23121618
3. Vigli D, et al. Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice. Neuroscience. 2021;453:113-123. PMID: 33010341
4. Takeda S, et al. Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. J Toxicol Sci. 2014;39(5):711-6. PMID: 25242400
5. Ruhaak LR, et al. Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids. Biol Pharm Bull. 2011;34(5):774-8. PMID: 21532172
6. Formato M, et al. (-)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound. Molecules. 2020;25(11):2638. PMID: 32503116
7. De Gregorio D, et al. Cannabidiol modulates serotonergic transmission and reverses allodynia and anxiety-like behavior. Pain. 2019;160(1):136-150. PMID: 30157131
8. Rock EM, et al. Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping. Br J Pharmacol. 2013;169(3):685-92. PMID: 23488964
9. Pertwee RG, et al. Cannabidiolic acid methyl ester produces 5-HT1A receptor-mediated suppression of nausea and anxiety. Br J Pharmacol. 2018;175(1):100-112. PMID: 29044616
10. Resstel LBM, et al. 5-HT1A receptors are involved in cannabidiol-induced attenuation of stress responses. Br J Pharmacol. 2009;156(1):181-8. PMID: 19133999
11. Costa B, et al. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of cannabidiol in acute inflammation. Br J Pharmacol. 2004;143(2):247-50. PMID: 15313881
12. Starkus J, et al. Diverse TRPV1 responses to cannabinoids. Channels (Austin). 2019;13(1):172-191. PMID: 31088309
13. Wakshlag JJ, et al. Pharmacokinetics of Cannabidiol, Cannabidiolic Acid and Related Metabolites. Front Vet Sci. 2020;7:505. PMID: 33102539
14. Anderson LL, et al. Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid. J Nat Prod. 2019. doi: 10.1021/acs.jnatprod.9b00600
15. Goerl B, et al. Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity. Epilepsy Res. 2021;169:106525. PMID: 33310415
16. Rock EM, et al. Evaluation of CBD, CBDA or CBDA methyl ester on nausea and vomiting. Psychopharmacology. 2020;237(9):2621-2631. PMID: 32488349
17. Aragona F, et al. Role of cannabidiolic acid in pain modulation in horses with chronic osteoarthritis. Front Vet Sci. 2024;11:1496473. PMID: 39720409
18. Kleinhenz MD, et al. Industrial hemp with high CBDA increases lying behavior and reduces stress biomarkers. Sci Rep. 2022;12(1):3683. PMID: 35256692
19. Rock EM, et al. Therapeutic potential of cannabidiol, cannabidiolic acid, and CBDA methyl ester for nausea and vomiting. Cannabis Cannabinoid Res. 2021. doi: 10.1089/can.2021.0041
20. Perucca E, Bialer M. Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination. CNS Drugs. 2020. PMID: 32504402
Natural Dos is not endorsed by, sponsored by, or affiliated with any research institution, journal, or author listed above. References are provided for informational purposes. Individual results may vary.