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HONEST ANSWERS

THE QUESTIONS WE GET MOST OFTEN.

What is the difference between CBDA and CBD? +

CBDA is the raw compound living hemp plants actually produce. CBD is what CBDA becomes when it is heated, a process called decarboxylation. Almost every manufacturer applies that heat during processing.

Your body absorbs CBDA over 500% more efficiently than CBD. That is the whole reason most CBD products disappoint people. Not because hemp does not work, but because they are getting the less bioavailable compound.

Calm+ leads with raw CBDA and pairs it with CBD, because CBD further enhances how much of the CBDA your body takes in.

Will Calm+ softgels make me feel high or fail a drug test? +

No. Calm+ softgels contain 0.0% THC, confirmed by third-party lab testing on every batch. No intoxication, no altered state, and no concern on a standard workplace screening.

I have tried CBD before and felt nothing. Why would this be different? +

Because standard oral CBD has a bioavailability of only around 6%. If you swallowed 25mg or 50mg of CBD, your body absorbed a small fraction of it.

Calm+ solves the absorption problem by leading with raw CBDA, which research puts at 5 to 10 times better absorbed. We also pair 50mg CBDA with 50mg CBD in organic MCT oil, which research indicates further boosts cellular uptake.

How quickly does it work, and how long does it last? +

Most people report physical softening, settled breathing and quieter thoughts within 15 to 30 minutes.

The steady release from organic MCT oil gives 6 to 8 hours of support, which is what makes it suited to sleeping through the night. With consistent daily use over 14 to 30 days, CBDA helps regulate your baseline so everyday stressors hit less hard.

How does the 100-day guarantee work with the BOGO package? +

Your purchase is risk-free. When your order arrives, open and use the first bottle for up to 100 days. If you are not satisfied with how you feel during the day or how you sleep at night, email [email protected].

Keep the bottle you opened with our compliments, send back the unopened second bottle on our prepaid return label, and we refund your full purchase price.

Your second bottle is free

Buy one bottle of doctor-formulated Calm+ CBDA softgels, get the second bottle free, with free US shipping and a 100-day money-back guarantee. Quieter evenings and deeper, uninterrupted sleep start tonight.

See full product details →

Scientific References

A selection of peer-reviewed research on cannabidiolic acid (CBDA), its pharmacology, its bioavailability, and its mechanisms of action in anxiety, sleep and endocannabinoid pathways.

PubMed British Pharmacological Society Journals PAIN Journal Nature Portfolio Springer Scientific Reports ACS Publications

1. Takeda S, et al. Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metab Dispos. 2008;36(9):1917-21. PMID: 18556441

2. Bolognini D, et al. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol. 2013;168(6):1456-70. PMID: 23121618

3. Vigli D, et al. Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice. Neuroscience. 2021;453:113-123. PMID: 33010341

4. Takeda S, et al. Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. J Toxicol Sci. 2014;39(5):711-6. PMID: 25242400

5. Ruhaak LR, et al. Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids. Biol Pharm Bull. 2011;34(5):774-8. PMID: 21532172

6. Formato M, et al. (-)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound. Molecules. 2020;25(11):2638. PMID: 32503116

7. De Gregorio D, et al. Cannabidiol modulates serotonergic transmission and reverses allodynia and anxiety-like behavior. Pain. 2019;160(1):136-150. PMID: 30157131

8. Rock EM, et al. Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping. Br J Pharmacol. 2013;169(3):685-92. PMID: 23488964

9. Pertwee RG, et al. Cannabidiolic acid methyl ester produces 5-HT1A receptor-mediated suppression of nausea and anxiety. Br J Pharmacol. 2018;175(1):100-112. PMID: 29044616

10. Resstel LBM, et al. 5-HT1A receptors are involved in cannabidiol-induced attenuation of stress responses. Br J Pharmacol. 2009;156(1):181-8. PMID: 19133999

11. Costa B, et al. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of cannabidiol in acute inflammation. Br J Pharmacol. 2004;143(2):247-50. PMID: 15313881

12. Starkus J, et al. Diverse TRPV1 responses to cannabinoids. Channels (Austin). 2019;13(1):172-191. PMID: 31088309

13. Wakshlag JJ, et al. Pharmacokinetics of Cannabidiol, Cannabidiolic Acid and Related Metabolites. Front Vet Sci. 2020;7:505. PMID: 33102539

14. Anderson LL, et al. Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid. J Nat Prod. 2019. doi: 10.1021/acs.jnatprod.9b00600

15. Goerl B, et al. Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity. Epilepsy Res. 2021;169:106525. PMID: 33310415

16. Rock EM, et al. Evaluation of CBD, CBDA or CBDA methyl ester on nausea and vomiting. Psychopharmacology. 2020;237(9):2621-2631. PMID: 32488349

17. Aragona F, et al. Role of cannabidiolic acid in pain modulation in horses with chronic osteoarthritis. Front Vet Sci. 2024;11:1496473. PMID: 39720409

18. Kleinhenz MD, et al. Industrial hemp with high CBDA increases lying behavior and reduces stress biomarkers. Sci Rep. 2022;12(1):3683. PMID: 35256692

19. Rock EM, et al. Therapeutic potential of cannabidiol, cannabidiolic acid, and CBDA methyl ester for nausea and vomiting. Cannabis Cannabinoid Res. 2021. doi: 10.1089/can.2021.0041

20. Perucca E, Bialer M. Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination. CNS Drugs. 2020. PMID: 32504402

Natural Dos is not endorsed by, sponsored by, or affiliated with any research institution, journal, or author listed above. References are provided for informational purposes. Individual results may vary.