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HONEST ANSWERS

THE QUESTIONS WE GET MOST OFTEN.

What's the difference between CBDA and CBD? +

CBDA is the raw compound the hemp plant naturally produces. CBD is what CBDA becomes when it's heated through a process called decarboxylation. Most hemp companies heat their product during purification, converting CBDA into CBD.

Your body absorbs CBDA over 500% more efficiently than CBD. That's the entire reason most CBD products disappoint people, not because hemp doesn't work, but because they're getting the less bioavailable compound.

Will any of these products make me feel high? +

No. CBDA Vegan Gummies contain zero THC, confirmed by third-party lab testing. No intoxication, no altered state, no drug-test concern.

I've tried CBD before and felt nothing. Why would CBDA be different? +

Because you were taking a compound with dramatically lower bioavailability. If your CBD was made using heat processing (which describes almost all of it), your body was absorbing a fraction of the dose listed on the label. CBDA doesn't have that problem, the absorption advantage is real and measurable. That's why we built the brand around it.

How long does it take to work? +

Stress and anxiety: many customers report noticing a difference within the first 30 minutes, and a few days for energy.
Sleep: most within the first week. Physical ease: tends to build over 2–4 weeks. We say give it 30 days to genuinely evaluate it. That's also why the guarantee is 100 days, you have time to actually know.

Your second jar is free

Buy one jar, get one free, with free shipping and a 100-day money-back guarantee. Calmer days and quieter nights start tonight.

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Scientific References

A selection of peer-reviewed research on cannabidiolic acid (CBDA), its pharmacology, and its mechanisms of action in pain, sleep, and inflammation pathways.

PubMed British Pharmacological Society Journals PAIN Journal Nature Portfolio Springer Scientific Reports ACS Publications

1. Takeda S, et al. Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metab Dispos. 2008;36(9):1917-21. PMID: 18556441

2. Bolognini D, et al. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol. 2013;168(6):1456-70. PMID: 23121618

3. Vigli D, et al. Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice. Neuroscience. 2021;453:113-123. PMID: 33010341

4. Takeda S, et al. Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. J Toxicol Sci. 2014;39(5):711-6. PMID: 25242400

5. Ruhaak LR, et al. Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids. Biol Pharm Bull. 2011;34(5):774-8. PMID: 21532172

6. Formato M, et al. (-)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound. Molecules. 2020;25(11):2638. PMID: 32503116

7. De Gregorio D, et al. Cannabidiol modulates serotonergic transmission and reverses allodynia and anxiety-like behavior. Pain. 2019;160(1):136-150. PMID: 30157131

8. Rock EM, et al. Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping. Br J Pharmacol. 2013;169(3):685-92. PMID: 23488964

9. Pertwee RG, et al. Cannabidiolic acid methyl ester produces 5-HT1A receptor-mediated suppression of nausea and anxiety. Br J Pharmacol. 2018;175(1):100-112. PMID: 29044616

10. Resstel LBM, et al. 5-HT1A receptors are involved in cannabidiol-induced attenuation of stress responses. Br J Pharmacol. 2009;156(1):181-8. PMID: 19133999

11. Costa B, et al. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of cannabidiol in acute inflammation. Br J Pharmacol. 2004;143(2):247-50. PMID: 15313881

12. Starkus J, et al. Diverse TRPV1 responses to cannabinoids. Channels (Austin). 2019;13(1):172-191. PMID: 31088309

13. Wakshlag JJ, et al. Pharmacokinetics of Cannabidiol, Cannabidiolic Acid and Related Metabolites. Front Vet Sci. 2020;7:505. PMID: 33102539

14. Anderson LL, et al. Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid. J Nat Prod. 2019. doi: 10.1021/acs.jnatprod.9b00600

15. Goerl B, et al. Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity. Epilepsy Res. 2021;169:106525. PMID: 33310415

16. Rock EM, et al. Evaluation of CBD, CBDA or CBDA methyl ester on nausea and vomiting. Psychopharmacology. 2020;237(9):2621-2631. PMID: 32488349

17. Aragona F, et al. Role of cannabidiolic acid in pain modulation in horses with chronic osteoarthritis. Front Vet Sci. 2024;11:1496473. PMID: 39720409

18. Kleinhenz MD, et al. Industrial hemp with high CBDA increases lying behavior and reduces stress biomarkers. Sci Rep. 2022;12(1):3683. PMID: 35256692

19. Rock EM, et al. Therapeutic potential of cannabidiol, cannabidiolic acid, and CBDA methyl ester for nausea and vomiting. Cannabis Cannabinoid Res. 2021. doi: 10.1089/can.2021.0041

20. Perucca E, Bialer M. Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination. CNS Drugs. 2020. PMID: 32504402

Natural Dos is not endorsed by, sponsored by, or affiliated with any research institution, journal, or author listed above. References are provided for informational purposes. Individual results may vary.