Hemp produces many different cannabinoids, and the most abundant and powerful is CBDA (cannabidiolic acid). But what is CBDA? 

This amazing compound is unique, and has over 500% better absorption than CBD, making it the most potent cannabinoid on the market. With our special formulation, Natural Spectrum CBDA oil can reach over 1000% better absorption than conventional CBD or CBDA on its own.

Our technology preserves all original cannabinoids found in the hemp plant. Find out for yourself why thousands of people use Natural Dos CBDA products as part of their regimen today, either for stress management, pain relief, sleep support, or any other number of CBDA benefits!

First things first – what is CBDA? Cannabidiolic acid, commonly known as CBDA, is the acidic precursor to cannabidiol (CBD), one of the most prevalent active compounds found in the Cannabis sativa plant. 

Unlike its well-known counterpart, CBD, which is widely recognized for its potential therapeutic applications, CBDA is less understood by the general public and often underrepresented in the conversation about cannabis-derived compounds.

CBDA is present in raw and live cannabis plants, where it exists in high concentrations, particularly in hemp varieties that are bred to contain lower levels of THC (tetrahydrocannabinol). 

The chemical structure of CBDA includes a carboxyl group (-COOH), which is responsible for its classification as an acid. This carboxyl group is a distinguishing feature that sets CBDA apart from CBD. 

When CBDA is exposed to heat or prolonged storage, it undergoes a process known as decarbing CBDA. During this chemical reaction, the carboxyl group is removed, and CBDA is converted into CBD. This transformation is significant because it alters the compound’s properties and potential interactions with the body’s endocannabinoid system (ECS).

With advancements in extraction and preservation technologies, it has become possible to isolate CBDA and formulate products that highlight its presence while minimizing the conversion to CBD. 

But what is CBDA becoming more popular for? Simple – the enhanced CBDA absorption rates mean that you can achieve the same effects as CBD with a lower dose. More on that below.

The hemp flower does not actually make CBD. Instead, it makes many acidic cannabinoids, with CBDA being the most abundant. All CBD is derived from CBDA after it has been heated during processing.

Like all acid cannabinoids, CBDA contains a carboxyl group (-COOH) that confers unique properties including enhanced bioavailability (how well a compound gets into the bloodstream).

Conventional processing requires heat, which in turn degrades the original CBDA molecule found in the hemp plant. Using heat for extraction compromises the quality of the original cannabinoids and reduces the potential health benefits.

Natural Dos contains the full spectrum of all the cannabinoids in their original state. We’ll talk about what makes our formulation the best CBDA tincture shortly. For now, let’s take a deeper look at the CBDA vs CBD conversation below.

Full spectrum CBD oil is well known as the most potent form of CBD oil from the hemp plant and contains all the cannabinoids from the hemp plant. However, these cannabinoids are all in their decarboxylated form, i.e. they were converted from their natural acidic form.

Natural Spectrum CBD oil is a proprietary hemp oil made by Natural Dos that contains all the acidic cannabinoids from the hemp plant. This can include CBGA, CBCA, THCVA, THCA, and others and provides an exceptional boost in CBDA bioavailability. This makes it the best CBDA oil on the market.

This unique Natural Dos formulation gets its potency by the superior absorption of all the acidic cannabinoids that synergize when taken together.

Like CBD, CBDA is a nonpsychoactive cannabinoid and will not get you high like its cousin THC. So – what is CBDA good for exactly? 

As the cannabinoid field continues to expand, CBDA oil has gained popularity for its many benefits as new uses and benefits are being discovered every day.

Anxiety and Stress

There are now a number of well-known mechanisms by which CBDA can help bring relaxation and calm to those who use it. In fact, CBDA for depression and CBDA for anxiety are two of the most common use cases for this cannabinoid. 

The endocannabinoid system (ECS) is found throughout the body but is well known for its role in the brain in regulating your mood. The ECS works in part through its 2 main receptors CB1 and CB2, which CBDA interacts with. There are now many published studies on how CBDA helps regulate the CB2 receptor, most commonly associated with CBD and its anxiety and stress-relieving properties.

Another underappreciated but well-studied impact of CBDA is on the serotonin receptor 5HT1A. CBDA can directly activate this receptor which is primarily found in the brain. This has significant implications for mood since this receptor is also a target for SSRIs (selective serotonin reuptake inhibitors) which are commonly prescribed for depression.

Interestingly, activation of the 5HT1A can also reduce blood pressure through vagus nerve stimulation. This is a well-known target for multiple blood pressure drugs and has been extensively studied.

Nausea Effects

Multiple pre-clinical studies have shown great promise in using CBDA for nausea. These studies have narrowed down the target to 5HT1A activation, which appears to help control nausea symptoms. 

This is not the first time cannabinoids have been used to treat nausea symptoms as this is a well-known approach for many chemotherapy patients.

Anti Inflammation Properties

A unique property of CBDA that was discovered over 10 years ago is its ability to both inhibit and decrease the production of COX-2 (cyclooxygenase 2). This shows potential to use CBDA for inflammation.

COX-2 is a well-known pro-inflammatory enzyme involved in most diseases where inflammation is causing damage. This enzyme is a common target for many NSAIDs (nonsteroidal anti-inflammatory drugs) such as Ibuprofen and Aspirin.

Pain Relief

There are numerous pre-clinical studies finding that you can also use CBDA for pain. This appears to be through two unique properties of CBDA, its effect on inflammation and COX-2 and its inhibition of the TRPV1 channel (Transient receptor potential vanilloid 1). The TRPV1 protein sits on the cell surface of many neurons and helps conduct pain signaling to the brain.

This is interesting because there has been a lot of work around using Capsaicin to inhibit pain through this exact mechanism. There are now prescription drugs on the market that use capsaicin to help with neuropathic pain.

Anti-Viral Properties

CBDA has received the most attention lately for a number of studies that came out showing that it can inhibit the Sars-Cov-2 virus from binding to epithelial cells.

This research has been performed in a number of in vitro studies and showed that with multiple different strains, it can inhibit both the binding and expression of some viral proteins.

However, the concentrations used in the studies translated for very high blood levels, and in vivo studies have yet to be performed.

Natural Dos stands out in the market with our proprietary Natural Spectrum CBDA oil, which boasts a remarkable absorption rate that is over 1000% better than conventional CBD or CBDA products. This enhanced bioavailability means that the body can utilize more of the CBDA, making the effects more potent and efficient.

Our commitment to quality is evident in our technology, which maintains the integrity of all original cannabinoids found in the hemp plant. By avoiding the use of heat in extraction, which typically degrades the original CBDA molecule, Natural Dos ensures that customers receive a full spectrum of all the cannabinoids in their original, acidic form. 

This approach not only preserves the efficacy of CBDA but also synergizes the effects of all acidic cannabinoids when taken together, offering a superior experience.

We have so many different products to choose from, too. From the basics like CBDA gummies and CBDA oil to unique formulations such as our CBDA mints and CBDA capsules, there is truly something for everyone in our catalog.

Plus, your order is protected by our 100-day, 100% money-back guarantee. So why not take a chance and see what CBDA can do for you? Learn more about what makes our products so special in the infographic below: