There are over 100 different cannabinoids found in cannabis sativa plants, each with its own unique characteristics and benefits to offer. While so much spotlight is placed on CBD and THC, we’re going to examine key differences between two lesser-known players today: CBDA vs CBDV.
Now, CBDV and CBDA are cousins but with cool, distinct features. CBDA has much better absorption than CBDV, and thus is considered the more potent cannabinoid of the two.
Grasping these differences could open up new avenues for your health and well-being. Just remember, checking in with your healthcare pro before integrating new cannabinoids in your routine is a must!
Behind this articleVegan Tropical CBDA GummiesCalm without the high. 50mg CBDA and 50mg CBD per gummy.See the gummies
While each has its place, the profound CBDA oil benefits are impossible to ignore. You’ll see why in just a moment. And, you’ll realize why it’s worth adding CBDA products from Natural Dos to your wellness regimen!
What is CBDV
Ever stumbled upon cannabidivarin (CBDV)? If not, let me introduce you! CBDV is one of those low-key guys among the cannabinoid compounds who don’t crave the limelight.
Like its famed cousin CBD, it won’t get you high. It’s sort of a rarity, it is typically found in very low amounts in the cannabis plant, especially in the landrace strains of cannabis sativa and cannabis indica.
CBDV, like all neutral cannabinoids, comes from CBDVA (Cannabidivarinic acid), which is in the acidic cannabinoids class. This class is defined by the presence of a carboxyl group, which is the natural state of cannabinoids.
In fact, you won't find CBDV in the cannabinoid biosynthesis pathway since all the major and minor cannabinoids are created in the “acidic” form. It is only during processing do you convert CBDVA into CBDV.
The Potential Perks of CBDV
Here’s how CBDV can potentially make a splash in your life:
- It’s a potential anti-seizure effects. In scientific lingo, we call this anticonvulsant properties – essentially it could help keep any unwanted seizures under control. These effects may be due to its interactions with the transient receptor potential vanilloid channels, such as TRPV1, involved in neuronal hyperexcitability.
- CBDV may have potential anti-inflammation effects. Its studied anti-inflammatory effects in vitro in nerve cells could be promising news if you’re looking to soothe something inflamed.
- Its potential superpower also stretches towards autism spectrum disorder – something scientists are eagerly exploring.
- Dealing with tummy trouble? CBDV might come to the rescue, potentially helping in reducing nausea.
However, the downside of CBDV is that all the research studies used very high concentrations. In animal studies, the concentrations used would translate to between 700mg to over 2000mg per dose.
In the one human trial, they used a dose of 600mg, and found some effects in patients with autism spectrum disorder.
These high doses highlight the poor absorption of the neutral cannabinoids compared to their acidic cannabinoid counterparts.
Intro to CBDA
Now, let’s introduce the other half of the CBDA vs CBDV conversation. What is CBDA? You can think of CBDA as CBD’s ‘parent.’ CBDA is found in raw, unprocessed cannabis and hemp plants, particularly in cannabis sativa.
So, how does humble cannabidiolic acid transform into the superstar CBD? Let’s take a little science trip. It’s all about the heat exposure. This process, called CBDA decarboxylation, occurs when you apply heat to the plant or extract, causing a chemical reaction that turns CBDA into CBD.
Many people are not familiar with CBDA or other acidic cannabinoids because conventional purification processes use heat, which destroys CBDA in the process.
New technologies developed at Natural Dos are able to isolate only acidic cannabinoids and create a Natural Spectrum CBDA oil with enhanced absorption.
But, why try CBDA? Cannabis researchers have started delving into the properties of CBDA and found a range of potential CBDA benefits:
- Anti-inflammatory: CBDA was found to inhibit the inflammatory enzyme COX-2 (cyclooxygenase 2). This enzyme is critical to stimulating inflammation and is the main target for many drugs like ibuprofen and aspirin. It’s why CBDA for inflammation is so promising, as you can use CBDA for pain.
- Anti-seizure: There are now multiple pre-clinical trials showing that CBDA can reduce the symptoms of seizures, similar to the effects found by CBD, but at lower doses.
- Enhanced absorption: Like other acidic cannabinoids, CBDA absorption is superior when compared to CBD - over 500% better to be specific. While we don't have a direct comparison of CBDA vs CBDV, we can assume they act like their other neutral cannabinoids.
- Stress and anxiety: CBDA has been studied in pre-clinical trials for stress and anxiety relief with promising results. The best results are reported by the many enthusiasts of CBDA oil though.
There are many other benefits too, including CBDA for nausea, CBDA for sleep, CBDA for depression, and more. Maybe you’re wondering though…does CBDA make you high?
CBDA is one of the nonpsychotropic plant cannabinoids, meaning it doesn’t get you high. It’s also among the many promising acidic cannabinoids found in cannabis sativa.
Subsequent studies are constantly uncovering more about CBDA’s chemical profile. Additionally, previously reported findings show many cannabinoid compounds work together, with CBDA being part of that team effort.
The enzyme producing CBDA in the plant is called CBDA synthase just like how THCA is produced by tetrahydrocannabinolic acid synthase. Both these synthases use the mother cannabinoid, CBGA (cannabigerolic acid), as a substrate to create either CBDA or THCA.
Comparing CBDA vs CBDV: What are the Key Differences?
Alright, now you’re familiar with CBDA and CBDV, let’s chat about what makes each of them unique. There’s a reason you hear a lot more talk about CBDA compared to CBDV, and that’s because it's better absorbed and offers more benefits. It’s also more accessible!
Bioavailability
CBDA is better absorbed than CBDV, and thus has higher bioavailability. This term refers to how well a compound is absorbed and gets into the bloodstream. For example, a 50mg dose of CBDA might have the same blood concentration as a 300mg dose of CBDV.
This is critical to determining the benefits since a poorly absorbed compound will not have significant effects unless used at much higher doses. It also means you need a lower CBDA dosage compared to CBDV to achieve similar results.
Potential Benefits
Both CBDA and CBDV have some similar properties, although at different doses.
- Pre-clinical trials show that both compounds have some anti-inflammatory effects. However, there are much fewer studies on CBDV at this point.
- Both compounds show anti-convulsant effects either in vitro or in animal models, but more work needs to be done for CBDV to elucidate how this is happening.
- Both CBDA and CBDV seem to interact with the TRPV1 channels involved in nerve cells signaling, however, CBDA appears to inhibit while CBDV may increase activation temporarily.
At this point, there is just not much research on CBDV. From what we do know, though, CBDA stands head and shoulders above CBDV.
Accessibility
When comparing CBDA and CBDV (Cannabidivarin), a key factor to consider is accessibility. CBDV, while promising in its potential benefits, is relatively scarce in the cannabis market.
This rarity stems from its lower presence in most hemp strains, making it more challenging and costly to extract in significant quantities. As a result, CBDV products are not as widely available as those containing more abundant cannabinoids like CBD or CBDA.
While you may struggle to find CBDV products, Natural Dos is proud to offer everything from the best CBDA tincture to CBDA gummies, CBDA mints, CBDA oil, and CBDA capsules.
We harness the natural abundance of CBDA in hemp through advanced extraction methods, ensuring that you have consistent access to high-quality products.
Our CBDA offerings cater to various preferences and needs, making it easy for anyone to incorporate this beneficial cannabinoid into their daily routine.
How Do These Cannabinoids Compare to Others?
As we said from the start of this conversation, there are hundreds of cannabinoids - many of which we still know very little about. However, we’ve written similar comparisons here at Natural Dos - such as CBDA vs CBG, CBDA vs CBD, hemp oil vs CBD, full spectrum vs broad spectrum CBD, and more.
We’re your trusted source for all things cannabis information, from the endocannabinoid system itself to potential CBDA side effects.
That being said, you can feel confident when you choose Natural Dos for a reliable, accessible path to harnessing the natural power of hemp-derived wellness. Shop now as we wrap up our comparison of CBDA vs CBDV.
Final Thoughts on CBDA vs CBDV
At this point, CBDV requires much further analysis by the scientific community before we really understand its unique mechanisms. CBDA is farther along the research track, and the acidic cannabinoids are receiving a lot of attention due to their high bioavailability.
Keep in mind, though, that we’re venturing through a brave new world of understanding these awesome cannabinoids. Our dedicated science people are constantly digging up new goodies and, while what we’ve got so far looks exciting, there’s heaps more to discover about their full potential.
Now, before we hit the road, let’s shoot straight for a minute. Safety first, always. Before you invite CBDA and CBDV to your health party, take a moment to have a talk with your doctor. After all, taking care of numero uno—you, that’s who!—should always top of your list when considering different supplements.
But remember - the finest CBDA tinctures and other products are just a click away at Natural Dos. Discover what a difference our products can make in your life today!
Behind this articleVegan Tropical CBDA GummiesCalm without the high. 50mg CBDA and 50mg CBD per gummy.See the gummies