Have you heard of CBDA oil but are not sure what it is? Maybe your friend uses CBD products, but they have not done much for you.
CBDA oil offers more substantial benefits thanks to its superior absorption, meaning you can take less to experience more. It has anti-inflammatory properties to aid in pain relief and can dial down your stress and anxiety. There’s even reason to believe it can help improve your sleep, fight nausea, and more.
We’ll highlight all the benefits of CBDA oil in this guide, and introduce you to the top CBDA products for sale online so you can experience these benefits firsthand.
For the first time, Natural Dos proprietary purification technology captures the natural CBDA oil found in cannabis plants, unlocking the powerful benefits of this mysterious little cannabinoid.
What is CBDA oil?
Let’s start with the basics before getting into benefits. Cannabinoids are a class of compounds found in hemp plants that interact with the endocannabinoid system. For reference, the term “cannabis plants” is used to refer to “hemp plants”.
In raw cannabis flowers, acidic cannabinoids are what the plant naturally produces. The major cannabinoid precursor compounds are all acidic cannabinoids, and cannabigerolic acid (CBGA) is the starting compound. CBGA is synthesized from its intermediate precursor olivetolic acid.
As seen in the figure below, the other acidic cannabinoids start with CBGA and can get converted to CBD, CBG, or THC during conventional processing:
Ok, so what is CBDA? Cannabidiolic acid (CBDA) is the natural form of CBD found in the hemp plant. The flower is the most abundant source of cannabinoids in the hemp plant, and CBDA is one of the most commonly found cannabinoids. It typically constitutes around 90% of all the other cannabinoids that are present in the flower. This figure shows the molecular change that occurs when CBDA gets decarboxylated to CBD. You can learn more about decarbing CBDA in our blog.
Cannabidiolic acid (CBDA), like CBD, is not psychoactive, and will not get you high. While CBDA oil products have been more difficult to come by compared to CBD products, they are starting to emerge on the market now.
The emergence of the potential benefits of CBDA and other acidic cannabinoids is leading to new technologies to better isolate high-purity full spectrum CBDA oil.
At Natural Dos, we have developed a Natural Spectrum CBDA Oil that contains all the therapeutic benefits of CBDA and the other minor acidic cannabinoids in our CBDA tinctures, gummies, and breath mints. More on that later. For now, let’s get into the benefits of CBDA oil.
What are the CBDA Oil Benefits That Have People Raving About This Cannabinoid?
So, what are the benefits of CBDA oil? To understand how this cannabinoid is able to deliver results for you, we need to start by discussing how it works in your body.
Let’s highlight the role of the endocannabinoid system before getting into the CBDA oil benefits you need to know about.
An Overview of the Endocannabinoid System
The endocannabinoid system is found throughout the body, and strongly impacts many physiological functions:
- Mood
- Immune function
- Inflammation
- Metabolism
- Sleep
The health benefits of hemp oil are largely thought to be derived from the effect of cannabinoids to help bolster the endocannabinoid system. It was originally thought that you had to decarboxylate CBDA to CBD in order to get the health benefits.
This is wrong.
CBDA interacts in multiple facets with the endocannabinoid system, such as through the cannabinoid receptors CB1 and CB2. Both cannabinoid receptors are classical targets for the endocannabinoids themselves (AEA and 2-DG), as well as cannabinoids from cannabis sativa. These receptors are found throughout the human body, with high expression in the central nervous system and immune system.
The psychoactive effects of THC are dependent on its specific action with the CB1 receptor, whereas CBDA and CBD are primarily interacting with the CB2 receptor. These interactions are complex, such as CBD being an inverse agonist that can modulate the drug metabolism of endogenous endocannabinoids themselves.
To summarize, CBDA oil can have significant impacts on the endocannabinoid system, and through multiple mechanisms including the CB2 receptor.
CBD oil has a longer history of human trials than CBDA oil due to its new emergence on the market. However, there is significant molecular overlap between CBDA vs CBD, as well as preclinical studies showing they may have similar functions.
So, what is CBDA good for? Let’s start to unpack the benefits of CBDA oil below.
CBDA Has Higher Absorption Than Other Cannabinoids
Researchers found that CBDA absorption is over 450% greater than CBD. This was found in multiple studies, and the enhanced absorption of CBDA oil is improved when taken in combination with cannabinoids.
Taking CBDA as a Natural Spectrum oil provides the greatest absorption. Absorption is the most critical element for cannabis compounds.
Most health benefits reported by clinical trials for CBD oil use very high doses because of the low absorption of CBD. This makes it cost-prohibitive for most consumers since taking 200mg per day is expensive.
The high absorption of CBDA oil solves this problem since 50mg of CBDA will reach similar levels as 250mg of CBD oil. In essence, you can take a much lower CBDA dosage and still yield impressive benefits!
CBDA Seizure control
CBD research has found success in treating seizures in patients with epilepsy. This is the only FDA approved CBD drug, and has shown significant improvements in controlling symptoms. Patients typically see doses ranging from 1000mg to 2000mg per day.
CBDA has also been reported to have significant anti-seizure properties in preclinical studies. This animal model of seizures compared CBD and CBDA, and found that both formulations were able to provide protection from seizures.
CBDA Anti inflammatory properties
Using CBDA’s anti inflammatory properties as a potential treatment in breast cancer cells has been reported in multiple studies. As such, there is reason to believe you can use CBDA for pain.
Early studies found that CBDA oil benefits may involve inhibition of the enzyme COX-2 (cyclooxygenase 2). This enzyme is critical in promoting many inflammatory responses, and is a target of nonsteroidal anti inflammatory drugs such as ibuprofen.
The effects of chronic inflammation on cancer cell growth is a well established field, and its role in breast cancer metastasis is a common target for many drugs.
Since CBDA was found to inhibit activity of COX-2, it was also tested in breast cancer cells to see if it could decrease inflammation and prevent the resulting growth. Treatment of CBDA oil with breast cancer cells decreased cancer cell growth and breast cancer metastasis in an in vitro model.
CBDA for Anxiety and Stress Relief
The cannabis plant has long been used to help with anxiety and stress, and is one of the main reasons customers typically say they use hemp oil. Both CBD and CBDA improved anxiety related scores in preclinical studies.
The mechanisms of how CBDA oil benefits anxiety symptoms may be from its ability to activate the 5HT1A receptor. This receptor is in a class of serotonin receptors, traditional targets for SSRI (selective serotonin reuptake inhibitor) used to treat depression.
The 5HT1A receptor is primarily located in the central nervous system, and can help regulate mood. We have a detailed guide on using CBDA for anxiety in our blog.
CBDA for Sleep
Emerging evidence suggests that CBDA may have potential as a sleep aid. This is likely due to its interactions with the endocannabinoid system, which plays a role in regulating sleep patterns. Unlike its counterpart CBD, which has been studied more extensively for its sedative effects,
CBDA may offer a different pathway to improved sleep by modulating neurotransmitter activity. It's thought that CBDA's influence on receptors, such as 5HT1A, could promote relaxation and help in the management of sleep disturbances. Learn more about CBDA for sleep in our blog.
CBDA for Digestive Health
The anti-inflammatory properties of CBDA might offer benefits for digestive health by reducing gut inflammation and potentially alleviating symptoms of gastrointestinal disorders.
Its interaction with the endocannabinoid system, which is active in the gut, could help in managing conditions like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), although direct evidence supporting this is still developing.
That being said, we’ve explored the use case of CBDA for nausea specifically in our blog. You can learn more about the link there if you’re interested.
CBDA for Neuroprotection
CBDA's potential neuroprotective effects are being explored, with the compound showing promise in preclinical models.
The antioxidant properties inherent in cannabinoids could protect brain cells from oxidative stress, a factor in neurodegenerative diseases. CBDA might also modulate the endocannabinoid system to support neuronal health, although the exact mechanisms and efficacy require more clinical research.
CBDA for Cardiovascular Health
CBDA may have a role in cardiovascular health due to its vasodilatory and anti-inflammatory effects. By potentially reducing arterial inflammation and affecting blood vessel function, CBDA could help lower the risk of hypertension and other cardiovascular diseases. However, studies specifically targeting CBDA's impact on heart health are limited, and further investigation is necessary.
CBDA and Immune System Modulation
The immunomodulatory effects of CBDA are an area of interest, with the compound possibly influencing the immune response through its interaction with cannabinoid receptors.
CBDA could aid in balancing the immune system, possibly reducing the occurrence of autoimmune reactions and inflammation.
This aspect of CBDA's potential benefits is still under study, and concrete evidence is needed to support its use as an immune system modulator.
CBDA for Skin Health
The anti-inflammatory and sebostatic properties of CBDA make it a candidate for addressing skin conditions like acne, eczema, and psoriasis.
By potentially inhibiting overactive sebaceous gland activity and reducing skin inflammation, CBDA could contribute to maintaining healthy skin. Anecdotal reports and preliminary studies support this idea.
More research is needed on the benefits of CBDA oil, and how it can improve health in the human body. Currently, the FDA has not approved CBDA for any treatment.
However, these early preliminary findings are promising - and the anecdotal evidence in favor of CBDA oil is overwhelming. That being said, why not try CBDA oil yourself and see what sort of benefits it has to offer? We’ll offer tips on getting started below.
Tips on Harnessing the Benefits of CBDA Oil
As you can see, there is an impressive list of CBDA oil benefits. So, how do you reap these benefits yourself and integrate this cannabinoid into your daily regimen? There are a couple of different products that CBDA oil comes in:
- Tinctures – CBDA tinctures are a great way to get the benefits of CBDA oil. Make sure to look for CBDA tinctures that have all the cannabinoids, i.e. Natural Spectrum CBDA or full spectrum CBDA.
- Gummies – Before buying CBDA gummies, make sure to check that it has a CoA and that it has the amount of CBDA in the test results that are listed on the labels. To make gummies requires heating of the pectin, and if not done right, will decarboxylate your CBDA when added.
- Breath Mints – Easy for on the go dosing of CBDA when you need to relax and tackle the day with great smelling breath. Check out Natural Dos CBDA breath mints.
- Hemp Flower – Hemp flower if it has not been stored in high heat for long periods of time should have lots of cannabidiolic acid (CBDA) in the flower. Check the date on the CoA to see how fresh it is. If you are looking for health benefits from CBDA, we do not recommend smoking flower. Heating organic material create carcinogens in the smoke.
- Capsules – Our CBDA capsules are a new addition to our catalog, but one we’ve been waiting on for some time. This is one of the most convenient ways to reap the benefits of CBDA oil as you just pop a capsule with your drink and let the ingredients work their magic with your endocannabinoid system!
As far as dosage, we recommend starting with 30mg to 50mg per serving. Try it once a day, and see how you feel and then move up or down from there.
Everyone has a different biochemistry, and this means their endocannabinoid system will respond differently. Whether it's CBDA capsules, CBDA tincture, or CBDA drops finding the right dosage where CBDA works for you may take a few tries.
Some customers use over 200mg per day and some get benefits with only 20mg a day, so there is a wide range.
Bringing Our Conversation on the CBDA Oil Benefits to a Close
CBDA oil from Natural Dos offers a spectrum of potential benefits, including enhanced absorption for more efficient dosing and potent anti-inflammatory effects that may aid in pain relief.
Its interaction with the endocannabinoid system could offer neuroprotective qualities and support digestive, cardiovascular, and immune health. Furthermore, its anti-inflammatory properties may benefit skin health and aid in sleep regulation, while also providing pain relief.
Otherwise, it’s time to get your hands on the best CBDA oil to reap these benefits firsthand. You’re just a few clicks away from harnessing the CBDA oil benefits here at Natural Dos, so what are you waiting for?
Discover the natural potency of CBDA oil for yourself at Natural Dos and tap into a world of holistic wellness. Shop now and experience the difference.
